Use and production

Probenecid is primarily used to treat gout and hyperuricemia.

Probenecid is sometimes used to increase the concentration of some antibiotics and to protect the kidneys when given with cidofovir. Specifically, a small amount of evidence supports the use of intravenous cefazolin once rather than three times a day when it is combined with probenecid.

Toxicity

Probenecid has also found use as a masking agent, potentially helping athletes using performance-enhancing substances to avoid detection by drug tests.

For this reason, Probenecid was included in the World Anti-Doping Agency Prohibited list.